GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs568617 | 1 | rs10791830 | chr11:65661291 | SNX32 | chr11:65601410-65621170:+ | 0.59 | 5.1 | 1.75E-6 | Crohn's disease |
| THYM | cis | rs6696239 | 1 | rs10799428 | chr1:227798565 | DUSP5P | chr1:228780657-228788159:+ | -0.77 | -4.8 | 5.93E-6 | Height |
| THYM | cis | rs495524 | 1 | rs10800501 | chr1:170128903 | SCYL3 | chr1:169821804-169863076:- | -0.23 | -4.17 | 6.81E-5 | Methotrexate phramacokinetics (acute lymphoblastic leukemia) |
| THYM | cis | rs10935120 | 1 | rs10804632 | chr3:134294501 | ANAPC13 | chr3:134196547-134204865:- | 0.55 | 7.52 | 3.08E-11 | Height |
| THYM | cis | rs10935120 | 1 | rs10804632 | chr3:134294501 | CEP63 | chr3:134204575-134293852:+ | 0.42 | 6.29 | 9.47E-9 | Height |
| THYM | cis | rs2243480 | 1 | rs10807701 | chr7:65724686 | CCT6P1 | chr7:65216092-65228661:+ | -0.64 | -5.29 | 7.77E-7 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs10807702 | chr7:65767843 | CCT6P1 | chr7:65216092-65228661:+ | 0.68 | 5.66 | 1.6E-7 | Diabetic kidney disease |
| THYM | cis | rs881375 | 1 | rs10818480 | chr9:123643170 | LOC253039 | chr9:123605320-123616644:+ | -0.62 | -5.62 | 1.91E-7 | Rheumatoid arthritis |
| THYM | cis | rs7849270 | 1 | rs10819464 | chr9:131876277 | CRAT | chr9:131857075-131873070:- | 0.38 | 4.61 | 1.24E-5 | Blood metabolite ratios |
| THYM | cis | rs7849270 | 1 | rs10819466 | chr9:131881492 | CRAT | chr9:131857075-131873070:- | 0.38 | 4.61 | 1.24E-5 | Blood metabolite ratios |
| THYM | cis | rs7849270 | 1 | rs10819469 | chr9:131882067 | CRAT | chr9:131857075-131873070:- | 0.42 | 4.98 | 2.82E-6 | Blood metabolite ratios |
| THYM | cis | rs7849270 | 1 | rs10819471 | chr9:131896325 | CRAT | chr9:131857075-131873070:- | 0.37 | 4.37 | 3.22E-5 | Blood metabolite ratios |
| THYM | cis | rs7301826 | 1 | rs10848205 | chr12:131280714 | STX2 | chr12:131274149-131323811:- | 0.33 | 5.6 | 2.1E-7 | Plasma plasminogen activator levels |
| THYM | cis | rs2275426 | 1 | rs1085243 | chr1:46544768 | CCDC163P | chr1:45960581-45965646:- | -0.49 | -6 | 3.55E-8 | Body mass index |
| THYM | cis | rs2275426 | 1 | rs1085244 | chr1:46563680 | CCDC163P | chr1:45960581-45965646:- | -0.49 | -6 | 3.55E-8 | Body mass index |